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Recent findings

We have recently developed expertise in the biology of AMP-activated protein kinase (AMPK), a nutritional and metabolic energy sensor, in cartilage homeostasis and OA. We have discovered that sustained AMPK activity in articular chondrocytes is critical for cartilage homeostatic balance, which provides a foundation to further explore the therapeutic potential of targeted activation of AMPK signaling in limiting and/or delaying the development and progression of OA. We have also found that pharmacologic activation of AMPK inhibits urate crystal-induced inflammation, and demonstrated that AMPK, at least in part, mediates the beneficial effect of low-dose colchicine for gout flare prophylaxis.

Recent grant support: VA Merit Review, NIAIMS, Arthritis Foundation.